Pneumonic Plague in Arizona: What You Need to Know
A recent death from pneumonic plague in Arizona marks the first such case in nearly two decades in the state. While this may seem alarming, this disease is extremely rare, and modern treatments significantly reduce fatality rates. The case has renewed public interest in understanding how plague spreads, the symptoms to recognize, and measures to minimize exposure. Awareness and early medical attention are key to preventing severe outcomes.
Understanding Pneumonic Plague
Pneumonic plague is one of three forms of plague caused by the bacterium Yersinia pestis. The classification depends on which part of the body the bacteria infect. Bubonic plague affects the lymph nodes and produces painful swellings called buboes. Septicemic plague spreads through the bloodstream and can result in multi-organ failure and shock. Pneumonic plague, however, infects the lungs and can be transmitted directly from person to person through airborne droplets. This form of the disease is particularly concerning because it can spread rapidly among close contacts if left untreated.
How Plague Spreads
The bacteria that cause plague can enter the body in multiple ways. Fleas that have bitten infected rodents can transmit the bacteria to humans, and direct contact with sick or dead animals, including rodents and cats, can also result in infection. Pneumonic plague may occur when bacteria spread to the lungs from an existing bubonic or septicemic infection, or when airborne droplets are inhaled. While the disease is transmissible, the risk to the general public remains very low, especially with prompt preventive and medical measures.

Symptoms of Pneumonic Plague
All forms of plague share general infectious symptoms such as fever, chills, headache, and weakness. Pneumonic plague, specifically, affects the lungs and manifests as rapidly progressing pneumonia with cough, shortness of breath, and chest pain. Early recognition of these symptoms is essential, as the disease can escalate quickly without medical intervention. Delays in treatment significantly increase the risk of severe complications or death. https://www.cdc.gov/plague/maps-statistics
Prevalence and Risk
Plague is extremely rare in the United States, with the CDC reporting an average of seven human cases annually. More than 80% of these cases are bubonic plague, while pneumonic cases are even less common. In the U.S., plague primarily occurs in regions including northern Arizona, northern New Mexico, southern Colorado, California, southern Oregon, and western Nevada. Globally, cases have been reported in parts of Africa, Madagascar, and Peru. Despite the recent Arizona case, the risk of widespread exposure remains very low.
Diagnosis and Treatment
Diagnosis of plague relies on laboratory testing of blood, sputum, or lymph node tissue. Because the disease progresses rapidly, prompt initiation of antibiotic therapy is critical. Effective antibiotics include gentamicin and fluoroquinolones, and when administered early, they significantly reduce the risk of fatal outcomes. Untreated pneumonic plague can have a fatality rate ranging from 30% to 100%, which highlights the importance of early recognition and treatment.

Prevention Measures
Residents in areas where plague has been reported can reduce their risk through basic preventive measures. Avoiding contact with wild animals, particularly sick or dead rodents, is essential. Controlling rodent populations around homes, maintaining a clean environment, and ensuring pets do not roam in rodent-prone areas further reduce risk. Flea control for pets and using repellents when outdoors can also help prevent transmission. While plague remains a rare disease, these precautions are effective in minimizing potential exposure and protecting both humans and animals.
Vaccination and Future Outlook
Currently, there is no plague vaccine available to the general public in the U.S., although vaccine candidates are under development. Most Americans do not need to worry about plague due to its rarity and the effectiveness of antibiotics. Public health authorities continue to monitor plague cases closely and advise preventive measures only in regions where the disease has been historically reported. Awareness, early diagnosis, and prompt treatment remain the most effective tools against pneumonic plague in Arizona.